Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.
Identifieur interne : 000F90 ( Main/Exploration ); précédent : 000F89; suivant : 000F91Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways.
Auteurs : Hin Chu ; Jie Zhou ; Bosco Ho-Yin Wong ; Cun Li ; Jasper Fuk-Woo Chan ; Zhong-Shan Cheng ; Dong Yang ; Dong Wang ; Andrew Chak-Yiu Lee ; Chuangen Li ; Man-Lung Yeung ; Jian-Piao Cai ; Ivy Hau-Yee Chan ; Wai-Kuen Ho ; Kelvin Kai-Wang To ; Bo-Jian Zheng ; Yanfeng Yao ; Chuan Qin ; Kwok-Yung Yuen [République populaire de Chine]Source :
- The Journal of infectious diseases [ 1537-6613 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux, Apoptose (physiologie), Callithrix, Cellules cultivées, Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Dipeptidyl peptidase 4 (génétique), Dipeptidyl peptidase 4 (métabolisme), Humains, Lymphocytes T (physiologie), Lymphocytes T (virologie), Rate (cytologie), Régulation de l'expression des gènes, Tonsille palatine (cytologie), Virus du SRAS (physiologie).
- MESH :
- cytologie : Rate, Tonsille palatine.
- génétique : Dipeptidyl peptidase 4.
- métabolisme : Dipeptidyl peptidase 4.
- physiologie : Apoptose, Coronavirus du syndrome respiratoire du Moyen-Orient, Lymphocytes T, Virus du SRAS.
- virologie : Lymphocytes T.
- Animaux, Anticorps antiviraux, Callithrix, Cellules cultivées, Humains, Régulation de l'expression des gènes.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral, Apoptosis (physiology), Callithrix, Cells, Cultured, Dipeptidyl Peptidase 4 (genetics), Dipeptidyl Peptidase 4 (metabolism), Gene Expression Regulation, Humans, Middle East Respiratory Syndrome Coronavirus (physiology), Palatine Tonsil (cytology), SARS Virus (physiology), Spleen (cytology), T-Lymphocytes (physiology), T-Lymphocytes (virology).
- MESH :
- chemical , genetics : Dipeptidyl Peptidase 4.
- chemical , metabolism : Dipeptidyl Peptidase 4.
- chemical : Antibodies, Viral.
- cytology : Palatine Tonsil, Spleen.
- physiology : Apoptosis, Middle East Respiratory Syndrome Coronavirus, SARS Virus, T-Lymphocytes.
- virology : T-Lymphocytes.
- Animals, Callithrix, Cells, Cultured, Gene Expression Regulation, Humans.
Abstract
Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus.
DOI: 10.1093/infdis/jiv380
PubMed: 26203058
Affiliations:
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Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for 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Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, Zhong Shan" sort="Cheng, Zhong Shan" uniqKey="Cheng Z" first="Zhong-Shan" last="Cheng">Zhong-Shan Cheng</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Andrew Chak Yiu" sort="Lee, Andrew Chak Yiu" uniqKey="Lee A" first="Andrew Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><affiliation><nlm:affiliation>Department of Microbiology.</nlm:affiliation><wicri:noCountry code="no comma">Department of Microbiology.</wicri:noCountry></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><affiliation><nlm:affiliation>Department of Surgery, University of Hong Kong, Hong Kong Special Administrative Region.</nlm:affiliation><wicri:noCountry code="subField">Hong Kong Special Administrative Region</wicri:noCountry></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><affiliation><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</nlm:affiliation><wicri:noCountry code="no comma">State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection.</wicri:noCountry></affiliation></author><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences.</nlm:affiliation><wicri:noCountry code="subField">Chinese Academy of Medical Sciences</wicri:noCountry></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="4"><nlm:affiliation>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases Department of Microbiology Research Centre of Infection and Immunology Carol Yu Centre for Infection Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University</wicri:regionArea><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName><orgName type="university">Université de Zhejiang</orgName></affiliation></author></analytic><series><title level="j">The Journal of infectious diseases</title><idno type="eISSN">1537-6613</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral</term><term>Apoptosis (physiology)</term><term>Callithrix</term><term>Cells, Cultured</term><term>Dipeptidyl Peptidase 4 (genetics)</term><term>Dipeptidyl Peptidase 4 (metabolism)</term><term>Gene Expression Regulation</term><term>Humans</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Palatine Tonsil (cytology)</term><term>SARS Virus (physiology)</term><term>Spleen (cytology)</term><term>T-Lymphocytes (physiology)</term><term>T-Lymphocytes (virology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Apoptose (physiologie)</term><term>Callithrix</term><term>Cellules cultivées</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Dipeptidyl peptidase 4 (génétique)</term><term>Dipeptidyl peptidase 4 (métabolisme)</term><term>Humains</term><term>Lymphocytes T (physiologie)</term><term>Lymphocytes T (virologie)</term><term>Rate (cytologie)</term><term>Régulation de l'expression des gènes</term><term>Tonsille palatine (cytologie)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dipeptidyl Peptidase 4</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Rate</term><term>Tonsille palatine</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Palatine Tonsil</term><term>Spleen</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Dipeptidyl peptidase 4</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Apoptose</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Lymphocytes T</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apoptosis</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>SARS Virus</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Callithrix</term><term>Cells, Cultured</term><term>Gene Expression Regulation</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux</term><term>Callithrix</term><term>Cellules cultivées</term><term>Humains</term><term>Régulation de l'expression des gènes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is associated with a mortality rate of >35%. We previously showed that MERS coronavirus (MERS-CoV) could infect human macrophages and dendritic cells and induce cytokine dysregulation. Here, we further investigated the interplay between human primary T cells and MERS-CoV in disease pathogenesis. Importantly, our results suggested that MERS-CoV efficiently infected T cells from the peripheral blood and from human lymphoid organs, including the spleen and the tonsil. We further demonstrated that MERS-CoV infection induced apoptosis in T cells, which involved the activation of both the extrinsic and intrinsic apoptosis pathways. Remarkably, immunostaining of spleen sections from MERS-CoV-infected common marmosets demonstrated the presence of viral nucleoprotein in their CD3(+) T cells. Overall, our results suggested that the unusual capacity of MERS-CoV to infect T cells and induce apoptosis might partly contribute to the high pathogenicity of the virus. </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Zhejiang</li></region><settlement><li>Hangzhou</li></settlement><orgName><li>Université de Zhejiang</li></orgName></list><tree><noCountry><name sortKey="Cai, Jian Piao" sort="Cai, Jian Piao" uniqKey="Cai J" first="Jian-Piao" last="Cai">Jian-Piao Cai</name><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><name sortKey="Cheng, Zhong Shan" sort="Cheng, Zhong Shan" uniqKey="Cheng Z" first="Zhong-Shan" last="Cheng">Zhong-Shan Cheng</name><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><name sortKey="Ho, Wai Kuen" sort="Ho, Wai Kuen" uniqKey="Ho W" first="Wai-Kuen" last="Ho">Wai-Kuen Ho</name><name sortKey="Lee, Andrew Chak Yiu" sort="Lee, Andrew Chak Yiu" uniqKey="Lee A" first="Andrew Chak-Yiu" last="Lee">Andrew Chak-Yiu Lee</name><name sortKey="Li, Chuangen" sort="Li, Chuangen" uniqKey="Li C" first="Chuangen" last="Li">Chuangen Li</name><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><name sortKey="Yeung, Man Lung" sort="Yeung, Man Lung" uniqKey="Yeung M" first="Man-Lung" last="Yeung">Man-Lung Yeung</name><name sortKey="Zheng, Bo Jian" sort="Zheng, Bo Jian" uniqKey="Zheng B" first="Bo-Jian" last="Zheng">Bo-Jian Zheng</name><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name></noCountry><country name="République populaire de Chine"><region name="Zhejiang"><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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